发明名称 |
PROCESS FOR THE PREPARATION OF PHARMACEUTICALLY ACTIVE THIAZOLIDINE OR OXAZOLIDINE COMPOUNDS BY A YEAST REDUCTASE |
摘要 |
A process for preparing a compound of formula (I), or a tautomeric form thereof and/or a pharmaceutically acceptable salt thereof and/or a pharmaceutically acceptable solvate thereof, wherein: T represents a substituted or unsubstituted aryl group and T<1> is O or S; which process comprises, treating a compound of formula (II), or a tautomeric form thereof and/or a salt thereof and/or a solvate thereof, wherein T and T<1> are as defined in relation to formula (I), with a microbial reductase obtained from an appropriate red yeast; and thereafter, as required, preparing a pharmaceutically acceptable salt and/or a pharmaceutically acceptable solvate of the compound of formula (I) or a tautomeric form thereof: compounds prepared by such a process and the use of such compounds in medicine. |
申请公布号 |
WO9310254(A1) |
申请公布日期 |
1993.05.27 |
申请号 |
WO1992GB02140 |
申请日期 |
1992.11.19 |
申请人 |
SMITHKLINE BEECHAM PLC. |
发明人 |
HINDLEY, RICHARD, MARK;WORONIECKI, STEFAN, ROLAND |
分类号 |
C12P17/00;A61K31/35;A61K31/42;A61K31/421;A61K31/425;A61K31/426;A61K31/44;A61P3/08;A61P3/10;C07D263/44;C07D277/20;C07D277/34;C07D413/12;C07D413/14;C07D417/12;C12P17/14;C12P17/16 |
主分类号 |
C12P17/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|