| 摘要 |
PURPOSE:To efficiently produce a 3-amino-cycloalkyloxypyridine useful as a raw material, etc., for synthesizing, e.g. an antipyretic, an analgetic, an anti- inflammatory medicine by heating and catalytically reducing a 6-chloro-2- cycloalkyloxy-3-nitropyridine in the presence of a palladium-carbon catalyst under pressure. CONSTITUTION:A 6-chloro-2-cycloalkyloxy-3-nitropyridine (e.g. 6-chloro-2- cyclohexyloxy-3-nitropyridine) represented by formula I (R is a 3 to 8C cycloalkyl) is heated and refluxed in the presence of hydrazine and a palladium- carbon catalyst in ethanol as the solvent for 3hr so as to be catalytically reduced. Thereby, the objective 3-amino-2-cycloalkyloxypyridine (e.g. 3-amino-2- cyclohexyloxypyridine) of formula II which is an important intermediate of a raw material for synthesizing a sulfonamidepyridine compound useful as an antipyretic, an analgetic, an anti-inflammatory, etc., can be produced in a high yield. |
