摘要 |
PCT No. PCT/EP93/01909 Sec. 371 Date Jan. 25, 1995 Sec. 102(e) Date Jan. 25, 1995 PCT Filed Jul. 20, 1993 PCT Pub. No. WO94/02467 PCT Pub. Date Feb. 3, 1994Compounds of general formula (I) <IMAGE> (I) wherein E is O or S; R is C1-C5 straight, branched or cyclic alkyl or C2-C5 alkenyl; X can be H, F, Cl, Br, I, CF3; n is an integer 1 to 4; m is an integer 0 to 4; A and B are 5- or 6- membered aromatic carbocyclic rings optionally containing one or more heteroatoms selected from N, O, S and carrying the substituents R1, R2 and R3, respectively; R1 can be hydrogen, halogen, C1-C4 alkoxycarbonyl, a sulfonic group or a tetrazole group of formula <IMAGE> or <IMAGE> wherein R4 can be hydrogen or C1-C5 alkyl; R2 can be hydrogen or a COOR4 group (wherein R4 is hydrogen or C1-C5 alkyl), CN, SO3H, PO3H or a tetrazole group R3; can be a hydrogen or a moiety of formula (II)B'(R'2,R'3)(II)wherein: B1, R12 have the same meanings reported above for B and R2, R'3 is H; with the proviso that when A is phenyl, R1 is different from H, and the pharmaceutically acceptable salts thereof. |