MICROSPHERES OF POLYHYDROXYLIC MATERIALS

摘要

Biodegradable polymeric microspheres useful for medical and other purposes are made of a polyhydroxylic polymer cross-linked by 1,1'-carbonyldiimidazole, phosgene or ethylchloroformate, the microspheres being directly reactive with nucleophiles. The microspheres are made by cross-linking an aqueous emulsion of the polymeric material using one of the above cross-linking agents. The polymer is usually a polysaccharide, and the microspheres can be directly linked to drugs, proteins and other diagnostic reagents, for example.