COMPOSITION COMPRISING NON-STEROIDAL ANTI-INFLAMMATORY AGENTAND EFFECTIVELY NON-ANTIBACTERIAL TETRACYCLINE

摘要

A method for treating mammals suffering from rheumatoid arthritis, other tissue-destructive conditions, and chronic inflammatory or other conditions associated with excess metalloproteinase activity comprising administering to the mammal an amount of a tetracycline that is effectively anti-metalloproteinase, but that is not effectively antimicrobial, and an amount of a non-steroidal antiinflammatory agent which, when combined with the effectively anti-metalloproteinase amount of tetracycline, results in a significant reduction of tissue destruction and/or bone loss.