PROCESS FOR PRODUCTION OF 3-[5-[4-(CYCLOPENTYLOXY)-2-HYDROXYBENZO YL]-2-[(3-HYDROXY-1,2-BEZISOXAZOL-6-YL)METHOXY]PHENYL]PROPIONATE ESTER AND INTERMEDIATE FOR THE PROCESS.

摘要

Disclosed is a production process using, as an intermediate, a 6-(halomethyl)-1,2-benzisooxazol-3(2H)-one derivative represented by the general formula: Wherein R5 represents a methyl group substituted by at least one phenyl group which may be substituted, or an oxygenated heterocyclic ring which may be substituted; and X represents a halogen atom. The process is useful for the production of 3-[5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(3-hydroxy-1,2-be nzisoxazol-6-yl)methoxy]phenyl]propionic acid, which is useful as an antirheumatic agent, in a high yield and in a safe and simple manner.