摘要 |
FIELD: medicine. ^ SUBSTANCE: preparation method of ball shaped pellets, containing (a) water soluble active ingredient, that is soluble, freely soluble or very soluble in the water and preferably has water solubility equal to >=0.5 g/ml; (b) agent, providing ball shape; (c) mono-, di- or triglycerides or their mixture. Indicated method comprises preparation of mixture, containing the active ingredient, agent, providing the bal shape, mono-, di- ot triglycerides or their mixture; and water volume less than of mixture full weight; extrusion of the indicated mixture with extrudate generation; and extrudate spheronization for preparation of the ball shaped pellets. Also invention relates to pellets, preparated by way of the indicated method, and measured dosage bands with sustained release for peroral intake, containing the indicated pellets. The method allows to prepare ball shaped pellets, containing water soluble medications, that allows to regulate release of active ingredient sample, providing a long-lasting powerful therapeutic effect. ^ EFFECT: provision long-lasting powerful therapeutic effect. ^ 12 cl, 2 ex |