PROCESS FOR THE PREPARATION OF 5-[[2(R)-[1(R)-[3,5-BIS(TRIFLUOROMETHYL)PHENYL] ETHOXY]-3(S)-(4-FLUOROPHENYL)-4-MORPHOLINYL]METHYL]-1,2-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE

摘要

The present invention is concerned with a novel process for the preparation of the compound 5-[[2(R)-[l(R)-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3(S)-(4-fluorophenyl)4-morpholinyl]methyl]-l,2-dihydro-3H-l,2,4-triazol-3-one. This compound is useful as a substance P (neurokinin-1) receptor antagonist. In particular, the compound is useful e.g., in the treatment of psychiatric disorders, inflammatory diseases and emesis.