| 发明名称 |
Soluble inhibitors of vascular endothelial growth factor and use thereof |
| 摘要 |
The present invention relates to cDNA encoding a soluble neuropilin protein (sNP) which is isolated from neuropilin (NP) producing cells or is recombinantly engineered from NP-encoding DNA. NP-1 and NP-2 are preferred NPs but any neuropilin or VEGF receptor (VEGFR), where the constituents share at least about 85% homology with either of the above VEGF<SUB>165</SUB>R/NP-1 and NP-2. More preferably, such constituent shares at least 90% homology. Still more preferably, each constituent shares at least 95% homology.
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| 申请公布号 |
US2008261867(A1) |
申请公布日期 |
2008.10.23 |
| 申请号 |
US20070893633 |
申请日期 |
2007.08.17 |
| 申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION |
发明人 |
KLAGSBRUN MICHAEL;SOKER SHAY;GAGNON MICHAEL L. |
| 分类号 |
A61K38/17;C12N15/09;A61K38/00;A61K48/00;A61P19/02;A61P27/02;A61P29/00;A61P35/00;A61P35/04;A61P43/00;C07K14/47;C07K14/71;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12N15/63 |
主分类号 |
A61K38/17 |
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