| 摘要 |
A novel crystal (B-type crystal) of 7-[2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamide-3-vinyl-3-cephem-4-carboxylic acid (a syn isomer) , characterized in that it exhibits peaks at diffraction angles shown in the following Table 1, in its powder X ray diffraction pattern: <tables id="TABLE-US-00001" num="00001"> <table frame="none" colsep="0" rowsep="0"> <tgroup align="left" colsep="0" rowsep="0" cols="1"> <colspec colname="1" colwidth="217pt" align="center"/> <THEAD> <ROW> <entry namest="1" nameend="1" rowsep="1">TABLE 1</ENTRY> </ROW> <ROW> <entry namest="1" nameend="1" align="center" rowsep="1"/> </ROW> <ROW> <ENTRY>Diffraction Angle 2theta (°)</ENTRY> </ROW> <ROW> <entry namest="1" nameend="1" align="center" rowsep="1"/> </ROW> </THEAD> <TBODY VALIGN="TOP"> <ROW> <ENTRY/> </ROW> </TBODY> </TGROUP> <tgroup align="left" colsep="0" rowsep="0" cols="2"> <colspec colname="offset" colwidth="77pt" align="left"/> <colspec colname="1" colwidth="140pt" align="left"/> <TBODY VALIGN="TOP"> <ROW> <ENTRY/> <ENTRY>approximately 11.7</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY>approximately 16.1</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY>approximately 18.6</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY>approximately 21.2</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY>approximately 22.3</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY>approximately 24.4</ENTRY> </ROW> <ROW> <ENTRY/> <ENTRY>approximately 26.2</ENTRY> </ROW> <ROW> <ENTRY/> <entry namest="offset" nameend="1" align="center" rowsep="1"/> </ROW> </TBODY> </TGROUP> </TABLE> </TABLES> This crystal is obtained by forming a crystal from a solution at a temperature of -5 to 5° C. in an acidic state. The crystal is not bulky, exhibits good stability and good filterability, and is excellent in the solubility toward water, and thus can be prepared with case.
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