发明名称 |
INFLUENZA POLYNUCLEOTIDES, EXPRESSION CONSTRUCTS, COMPOSITIONS, AND METHODS OF USE |
摘要 |
<p>The invention provides isolated RNA molecules containing a stretch of nucleotides from a conserved Influenza sequence, and provides complementary RNA molecules thereto. The RNA molecules of the invention are also substantially non-homologous to human sequences. The RNA molecules of the invention include double-stranded RNAs comprising a first region that is a conserved Influenza sequence, and a second region that is at least substantially complementary to the first region. Such double-stranded RNAs include single short hairpin RNAs (shRNAs) as well as multi-target hairpin RNAs containing a plurality, or several, stem-loop structures. The present invention further provides expression constructs that provide for expression of one, or a plurality, of RNA molecules of the invention. The RNA molecules, expression constructs, and compositions of the present invention find use in reducing levels of Influenza A RNA, in reducing Influenza A virus titer, and in treating or preventing Influenza virus infection. The invention is effective against at least human, swine and avian originating strains of Influenza A, and makes gene-silencing therapeutic strategies for combating Influenza A infection feasible.</p> |
申请公布号 |
WO2008128176(A1) |
申请公布日期 |
2008.10.23 |
申请号 |
WO2008US60222 |
申请日期 |
2008.04.14 |
申请人 |
NUCLEONICS, INC.;PACHUK, CATHERINE, J.;MCCALLUS, DANIEL, E. |
发明人 |
PACHUK, CATHERINE, J.;MCCALLUS, DANIEL, E. |
分类号 |
A01N43/04;C07H21/02;C07H21/04;C12N5/00;C12N5/02;C12N15/00 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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