TWELVE-MEMBERED CYCLOMACROLACTAM DERIVATIVE

摘要

This invention provides a twelve-membered cyclomacrolactam derivative having antitumor activity, more specifically a compound represented by formula (1) or its salt. In formula (1), R<SUB>1</SUB> represents a hydrogen atom, a C<SUB>1-6</SUB> alkyl group, a C<SUB>1-6</SUB> alkylcarbonyl group, or a C<SUB>6-14</SUB> arylcarbonyl group; R<SUB>2</SUB> represents a hydrogen atom or a C<SUB>1-6</SUB> alkyl group; R<SUB>3</SUB> represents a hydrogen atom or a hydroxyl group; R<SUB>4</SUB> represents a hydrogen atom or a hydroxyl group; R<SUB>5</SUB> represents a hydrogen atom or a C<SUB>1-6</SUB> alkyl group; R<SUB>6</SUB> represents a hydrogen atom or a hydroxyl group; and R<SUB>7</SUB> represents an acetyl group or the like.