| 摘要 |
<p>The method relates to the production of essentially pyrogene-free calcium phosphate starting from one or more calcium phosphate educts having a Ca/P molar ratio in the range of 1.00 to 2.00 and being formed in a pre-determined shape which remains essentially the same during the following procedural steps: A) transforming said educt(s) at least partly to beta-tricalcium phosphate (a-TCP), alpha-tricalcium phosphate (a-TCP), tetracalcium phosphate.(TetCP) or a mixture thereof at a temperature above 600°C; B) cooling down the material obtained in step A with said ß-TCP, a-TCP, TetCP or a mixture thereof to below 600°C; C) reacting the material obtained in step B with said ß-TCP, a-TCP, TetCP or a mixture thereof with water in gas or liquid phase or in an aqueous Solution at a temperature above room temperature to obtain an end-product which is essentially pyrogene-free. The pyrogene-free calcium phosphate obtained as an end-product by the method according to the invention can be advantageously used as a bone fixation or bone replacement implant or as a surface layer for a bone fixation or bone replacement implant.</p> |
