| 摘要 |
CeIl lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods. More particul arly, the invention relates to diverse human melanoma cell lines for the tre atment of malignant diseases, wherein the cell lines are: (a) MeI-XYl (depos ited at German Collection of Microorganisms and Cell Cultures DSMZ under acc ess number DSM ACC2830), (b) Mel-XY2 (deposited at Germán Collection of Micr oorganisms and Cell Cultures DSMZ under access number DSM ACC2831), (c) Mel- XY3 (deposited at Germán Collection of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2832), (d) Mel-XX4 (deposited at Germán Collecti on of Microorganisms and Cell Cultures DSMZ under access number DSM ACC2829) , or (e) sub-populations thereof. The cell lines may be irradiated, thus obt aining populations with apoptotic phenotype, and populations with necrotic p henotype of such lines. The compositions may comprise adjuvants and/or immun o-modif iers, and/or autologous dendritic cells.
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