The invention relates to gene suppression and replacement. In particular, the invention relates to enhanced expression of suppression agents for supp ressing gene expression in a cell and in vivo and replacement nucleic acids that are not inhibited by the suppression agent. Regulatory elements are inc luded in expression vectors to optimize expression of the suppression agent and/or replacement nucleic acid.
申请公布号
CA2683469(A1)
申请公布日期
2008.10.23
申请号
CA20082683469
申请日期
2008.04.14
申请人
THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVID ED
