A BIODEGRADABLE MICROSPHERE COMPOSITION SUITABLE FOR THE CONTROLLED RELEASE OF GLUCOSE CONTROLLING PEPTIDE AND FORMULATION THEREOF

摘要

A biodegradable microsphere is provided to allow the zero-order release of drugs over a prolonged period of time, thereby improving the therapeutic effect of the drug. A biodegradable microsphere capable of releasing a glucose-regulating peptide in a controlled manner comprises a biodegradable polymer carrier with the glucose-regulating peptide encapsulated therein, wherein the glucose-regulating peptide is selected from the group consisting of synthetic exedin-3, exedin-4, and homologs and agonists thereof and the biodegradable polymer is selected from the group consisting of poly-L-lactic acid, poly-D-lactic acid-co-glycolic acid, poly-L-lactic acid-co-glycolic acid and poly-D, L-lactic acid-co-glycolic acid. A method for preparing the biodegradable polymer microsphere comprises the steps of: (a) adding an organic solvent to a polymer to prepare a polymer solution; (b) dispersing a glucose-regulating peptide in the polymer solution to prepare a drug dispersion and mixing an alcohol or a mixture of an alcohol and an organic acid with the drug dispersion to prepare a drug-dispersed solution; and (c) producing a microsphere from the drug-dispersed solution. The organic solvent in the step (a) is selected from methylenechloride, ethylacetate and chloroform, and the alcohol in the step (b) is methyl alcohol.