THERAPEUTIC AGENT FOR INFLAMMATORY BOWEL DISEASE COMPRISING 2-AMINO-1,3-PROPANAEDIOL DERIVATIVE AS ACTIVE INGREDIENT, AND METHOD FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE.

摘要

Disclosed is a 2-amino-1,3-propanediol derivative represented by the formula (1) (e.g., 2-amino-2-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]ethyl- 1,3-propanediol hydrochloride), which is a sphingosine-1-phosphate receptor agonist, or a pharmaceutically acceptable salt or solvate thereof. It is found that the derivative, salt or solvate is useful as a therapeutic agent or a prophylactic agent for an inflammatory bowel disease such as Crohnâ¿¿s disease, Crohnâ¿¿s disease of large intestine, intestinal Behcetâ¿¿s disease, ulcerative colitis, hemorrhagic rectal ulcer or pouchitis.