发明名称 Methods for Reducing Seizure-Induced Neuronal Damage
摘要 This invention provides a method for treating a subject either during or soon after a seizure, in order to reduce the extent of neuronal damage in the subject resulting from the seizure comprising administering to the subject, either during or soon after the seizure, a therapeutically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to thereby reduce the extent of neuronal damage in the subject. This invention further provides a method for inhibiting neuronal damage which would otherwise result from a seizure in a subject predisposed to having a seizure, comprising administering to the subject a prophylactically effective amount of an inhibitor of receptor for advanced glycation endproducts (RAGE), so as to inhibit neuronal damage which would otherwise result from a seizure in the event the subject were to suffer a seizure.
申请公布号 US2008260717(A1) 申请公布日期 2008.10.23
申请号 US20040577382 申请日期 2004.10.28
申请人 TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 发明人 YAN SHI DU;MCKHANN GUY;STERN DAVID M.
分类号 A61K39/395;A01K67/027;A61K31/7052;A61K48/00;A61P25/00;C07H21/04;C07K14/705;C12N15/85;C12Q1/68 主分类号 A61K39/395
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