SIRNA AGAINST THYMIDYLATE SYNTHASE AND USES THEREOF IN CANCER TREATMENT REGIMENS

摘要

Small interfering RNA (siRNA) molecules that target a mammalian thymidylate synthase gene (TS), and which are capable of inhibiting the expression of their target gene, are provided The siRNA molecules are also capable of sensitizing cells to the effects of other anti-cancer agents, particularly chemotherapeutic agents that target TS Methods of treating cancer using the TS siRNA in combination with another anti-cancer agent are also provided Methods of enhancing the effect of a TS siRNA on cancer cell proliferation by combining the TS siRNA with a siRNA targeting a cell survival gene such as Bcl-2 are further provided.