发明名称 |
SYNTHESIS OF HUMAN SECRETORY IgA AND IgM AND THE FORMATION OF A MEDICAMENT THEREFROM |
摘要 |
A composition for treating a subject is provided. The composition includes antigen specific dimeric secretory IgA and pentameric IgM therapeutic. A process for manufacturing a medicament for the treatment of C. difficile associated disease in a human is also provided that the modification of antigen specific dimeric secretory IgA and pentameric IgM with secretory component to form a antigen specific dimeric secretory IgA and pentameric secretory IgM therapeutic. The antigen specific dimeric secretory IgA and the pentameric secretory IgM therapeutic is then mixed with formulating agents to create a capsule, tablet, liquid or suppository dosing form. The therapeutic is amenable to enrobement directly through microencapsulation or the dosing form is coated with an enteric coating. A method of C. difficile treatment with the therapeutic is also provided that is amenable to supplementation with concurrent or prior antibiotic administration. |
申请公布号 |
US2008260822(A1) |
申请公布日期 |
2008.10.23 |
申请号 |
US20080138758 |
申请日期 |
2008.06.13 |
申请人 |
|
发明人 |
SIMON MICHAEL R.;CHERVIN STEPHANIE M.;BROWN STEPHEN C. |
分类号 |
A61K9/48;A61K9/28;A61K39/44;A61P31/04 |
主分类号 |
A61K9/48 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|