| 发明名称 |
DIPHENYL-DIHYDRO-IMIDAZOPYRIDINONES |
| 摘要 |
<p>This invention is related to a compound of formula (1) and the pharmaceutically acceptable salts thereof, wherein X, R<SUP>1</SUP>, R<SUP>2</SUP>, Y<SUP>1</SUP> and Y<SUP>2</SUP> are as described herein. These compounds inhibit the interaction of MDM2 protein with a p- 53-like peptide and therefore exhibit antiproliferative activity.</p> |
| 申请公布号 |
WO2008125487(A1) |
申请公布日期 |
2008.10.23 |
| 申请号 |
WO2008EP53903 |
申请日期 |
2008.04.02 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG;ROMYR, DOMINIQUE;GOODNOW, ROBERT ALAN;QIAO, QI;VU, BINH THANH |
发明人 |
ROMYR, DOMINIQUE;GOODNOW, ROBERT ALAN;QIAO, QI;VU, BINH THANH |
| 分类号 |
C07D471/04;A61K31/437;A61P35/00 |
主分类号 |
C07D471/04 |
| 代理机构 |
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