| 摘要 |
Disclosed herein are molecule-modified nanoparticles and methods of makin g and using the same. More specifically, disclosed herein are molecule-modif ied nanoparticles wherein the molecule is attached to the surface of the nan oparticle via an oligonucleotide. Also disclosed are methods of preparing na noparticles having oligonucleotides and molecules (e.g., biomolecules, such as proteins, peptides, antibodies, lipids, and/or carbohydrates) attached to the nanoparticle surface, wherein the oligonucleotide and molecule are cova lently attached. Further disclosed are methods of detecting an analyte of in terest using these disclosed molecule-modified nanoparticles.
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