| 摘要 |
The present invention relates to methods of treating or preventing addict ion and relapse use of addictive agents, and treating or preventing addictiv e or compulsive behaviour and relapse practice of an addictive behaviour or compulsion, by administering a peroxisome proliferator-activated receptor ga mma (PPAR.gamma.) agonist, alone or in combination with another therapeutic agent, such as, for example, an opioid receptor antagonist or an antidepress ant. The present invention also includes pharmaceutical compositions for tre ating or preventing addiction or relapse that include a PPAR.gamma. agonist and one or more other therapeutic agents, as well as unit dosage forms of su ch pharmaceutical compositions, which contain a dosage effective in treating or preventing addiction or relapse. The methods and compositions of the inv ention are useful in the treatment or prevention of addiction to any agent, including alcohol, nicotine, marijuana, cocaine, and amphetamines, as well a s compulsive and addictive behaviours, including pathological gambling and p athological overeating.
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