发明名称 |
CELL LINE HAVING A HIGH TRANSCRIPTION ACTIVITY FOR THE PRODUCTION OF PROTEINS, IN PARTICULAR THERAPEUTIC PROTEINS |
摘要 |
The invention relates to a method for obtaining a cell line, that comprises the steps of integrating into the genome of said cell a unique site for the recognition of a recombinase in an area of high transcription activity of the genome of said cell, and integrating in the genome of said cell, and downstream from the unique recombinase recognition site, a nucleic acid sequence coding for a transcription termination signal. The invention also relates to cell lines obtained by said method. |
申请公布号 |
WO2008096070(A3) |
申请公布日期 |
2008.10.23 |
申请号 |
WO2007FR02144 |
申请日期 |
2007.12.20 |
申请人 |
LFB BIOTECHNOLOGIES SOCIETE PAR ACTIONS SIMPLIFIEE UNIPERSONNELLE;GAUCHER, CHRISTINE;SIRAC, CHRISTOPHE |
发明人 |
GAUCHER, CHRISTINE;SIRAC, CHRISTOPHE |
分类号 |
C12N15/85 |
主分类号 |
C12N15/85 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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