发明名称 |
N-HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)PHENOXY]PENTOXY}BENZAMIDINE 2 ETHANSULFONIC ACID SALT, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
摘要 |
An N- hydroxy-4- benzamidine 2 ethansulfonic acid salt is provided to show excellent solubility, stability, and bioavailability, as well as a higher initial release rate than 2 methansulfonic acid salt thereof. An N-hydroxy-4-benzamidine 2 ethansulfonic acid salt is represented by a formula(1) and is prepared by reacting N- hydroxy-4-benzamidine and ethanesulfonic acid in an inert solvent. A pharmaceutical composition for preventing and treating osteoporosis, bone fractures, allergic or inflammatory diseases comprises the N- hydroxy-4-benzamidine 2 ethansulfonic acid salt and a pharmaceutically acceptable carrier. An oral formulation for preventing and treating osteoporosis, bone fractures, and allergic inflammatory diseases, comprises the N- hydroxy-4-benzamidine 2 ethansulfonic acid salt along with (a) at least one carbonate selected from the group consisting of alkali metal carbonate, alkali metal bicarbonate and alkaline earth metal carbonate; (b) at least one disintegrant selected from the group consisting of sodium carboxymethyl starch, sodium carmellose, calcium carmellose and sodium croscarmellose; or a combination of (a) and (b).
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申请公布号 |
KR20080094634(A) |
申请公布日期 |
2008.10.23 |
申请号 |
KR20080036880 |
申请日期 |
2008.04.21 |
申请人 |
DONG WHA PHARM. IND. CO., LTD. |
发明人 |
LEE, JIN SOO;CHO, SOON KI;SEONG, SEUNG KYOO;JIN, YOUNG GOO;PARK, JAE HOON;KIM, BO KYUNG;CHA, JA HYUN;CHO, EUN HEE;RYU, JEI MAN |
分类号 |
C07D277/24;A61K31/426 |
主分类号 |
C07D277/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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