发明名称 |
Metabolic Engineering of Xylos Fermentation |
摘要 |
The present invention relates to further genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers the host cell the ability of isomerising xylose to xylulose. The further genetic modifications are aimed at improving the efficiency of xylose metabolism and include e.g. reduction of unspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source.
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申请公布号 |
US2008261287(A1) |
申请公布日期 |
2008.10.23 |
申请号 |
US20050632644 |
申请日期 |
2005.07.15 |
申请人 |
WINKLER AARON ADRIAAN;KUYPER SIPKO MAARTEN;DE LAAT WILHELMUS THEODORUS AN;VAN DIJKEN JOHANNES PIETER;PRONK JACOBUS THOMAS |
发明人 |
WINKLER AARON ADRIAAN;KUYPER SIPKO MAARTEN;DE LAAT WILHELMUS THEODORUS ANTONIUS MARIA;VAN DIJKEN JOHANNES PIETER;PRONK JACOBUS THOMAS |
分类号 |
C12P7/06;C12N1/14;C12N1/16;C12N1/18;C12P7/00;C12P7/08 |
主分类号 |
C12P7/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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