COLORIMETRIC DETECTION OF METALLIC IONS IN AQUEOUS MEDIA USING FUNCTIONLIZED NANOPARTICLES
摘要
Disclosed herein are methods of detecting metal ions in a sample using functionalized nanoparticles. More specifically, functionalized nanoparticles are used to selectively detect metal ions in a sample using changes in melting temperature of hybridized oligonucleotides on functionalized nanoparticles. The melting temperature can be detected using absorbance, color change, or both. In some cases, the concentration of the metal ion in the sample can be determined. Concentrations of metal ion of as little as 20 ppb (about 100 nM) can be detected using the disclosed methods.
申请公布号
WO2008127414(A2)
申请公布日期
2008.10.23
申请号
WO2007US84026
申请日期
2007.11.08
申请人
NORTHWESTERN UNIVERSITY;MIRKIN, CHAD, A.;LEE, JAE-SEUNG;HAN, MIN, SU