摘要 |
<p>The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non- polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m<SUP>2</SUP>/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.</p> |
申请人 |
BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM;THE DOW CHEMICAL COMPANY;WILLIAMS, ROBERT, O., III;JOHNSTON, KEITH, P.;SINWAT, PRAPASRI;MCCONVILLE, JASON, T.;TALBERT, ROBERT;PETERS, JAY;WATTS, ALAN, B.;ROGERS, TRUE, L. |
发明人 |
WILLIAMS, ROBERT, O., III;JOHNSTON, KEITH, P.;SINWAT, PRAPASRI;MCCONVILLE, JASON, T.;TALBERT, ROBERT;PETERS, JAY;WATTS, ALAN, B.;ROGERS, TRUE, L. |