| 摘要 |
The invention provides methods for predicting responsiveness to a biologi c agent in a subject suffering from psoriasis. The methods involve assaying for the presence or absence of an allele or polymorphism in the subject that is predictive of responsiveness to biologic therapy, such as an HLA-Cw6 all ele, a TNF.alpha. 238 polymorphism or a TNF.alpha. 308 polymorphism. The met hods can further comprise selecting a treatment regimen with a biologic agen t in a psoriasis subject based upon presence or absence of the allele or pol ymorphism in the subject. The methods can further comprise administering a b iologic agent to the subject according to the selected treatment regimen. Ki ts that include means for assaying an allele or polymorphism that is predict ive of responsiveness to biologic therapy for psoriasis are also provided. M ethods of preparing and using databases, and computer program products there fore, for selecting a psoriasis subject for treatment with a biologic agent are also provided.
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