OXAZOLIDINONE ANTIBIOTIC DERIVATIVES

摘要

The invention relates to antibacterial compounds of formula (I) wherein R 1 is hydrogen, halogen, hydroxy, alkoxy or cyano; Y1 and Y2 each represent C H, one or two of U, V, W and X represent(s) N and the remaining each represe nt CH or, in the case of X, may also represent CRa, Ra being halogen, and, i n the case of W, may also represent CRb, or each of U, V, W, X, Y1 and Y2 re presents CH, or each of U, V, W, X and Y1 represents CH and Y2 represents N, or also one or, provided R1 is hydrogen, two of U, V, W, X, Y1 and Y2 repre sent(s) CRC and the remaining each represent CH, Rb being alkoxy, alkoxycarb onyl or alkoxyalkoxy and Rc being, each time it occurs, independently repres ents hydroxy or alkoxy; A-B-D represents a chain of 4 to 6 atoms, which 4 to 6 atoms are seleted from carbon, oxygen and nitrogen and may be substituted ; E is one of the following groups: in which Z is CH or N and Q is O or S, o r E is a phenyl group which is substituted once or twice in the meta and/or para position(s); and to salts of such compounds.