17ALPHA-SUBSTITUTED STEROIDS AS SYSTEMIC ANTIANDROGENS AND SELECTIVE ANDROGEN RECEPTOR MODULATORS

摘要

Compounds having the structure, their salts or N-oxide derivatives: are u sed to treat or reduce le likelihood of acquiring androgen-dependent disease s, such as prostate cancer, benign prostatic hyperplasia, polycystic ovarian syndrome, acne, hirsutism, seborrhea, androgenic alopecia and male baldness . They can be formulated together with pharmaceutically acceptable diluent o r carrier or otherwise made into any pharmaceutical dosage form. Combination s with other active pharmaceutical agents are also disclosed.