THERAPEUTIC AGENT FOR HYPERTENSION

摘要

Disclosed is a novel therapeutic agent for prehypertension or hypertension, which has a different xanthine oxidase inhibitory activity from that of a conventional hypotensive agent used in clinical practice, and which is more effective compared to compounds which are reported to be xanthine oxidase inhibitors. Specifically disclosed is an aryl carboxylic acid derivative represented by the general formula (I), which can be used as an active ingredient for the therapeutic agent, and which has a potent xanthine oxidase inhibitory activity and an excellent hypotensive activity relying on the xanthine oxidase inhibitory activity. The aryl carboxylic acid derivative is useful as a novel therapeutic agent for prehypertension or hypertension which is different from a conventional hypotensive agent. (I) wherein the ring A represents an aryl or heteroaryl which may be substituted by a specific group; and the ring B represents a monocyclic heteroaryl which may be substituted by a specific group.