| 摘要 |
The present invention provides a device and a method for the enhanced ret inal delivery of nucleic acid therapeutics utilizing iontophoresis to evoke a transient elongation of the Muller Cells of a mammalian eye. The enhanced retinal deposition can be achieved by either a topical application, subconju nctival, or an intravitreal injection of the nucleic acid composition follow ed by, preceded by, or administered simultaneously with the iontophoretic ap plication. The present invention thus provides a particularly advantageous m ethod for the treatment of ocular diseases comprising the in vivo administra tion of a nucleic acid capable of alleviating the symptoms of a disease, the delivery of the nucleic acid being enhanced by using iontophoresis. This me thod can be applied particularly to the diseases of the retina resulting fro m an alteration of a gene expression and/or the over-expression of particula r growth factors. The diseases include, but are not limited to, human ocular retinopathies including, neovascular diseases (Age-Related Macular Edema, D iabetic Retinopathies, Diabetic Macular Edema, etc.) and inherited retinopat hies such as retinitis pigmentosa.
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