发明名称 |
Formulation of active agent loaded activated PLGA nanoparticles for targeted cancer nano-therapeutics |
摘要 |
The present invention includes compositions and methods of making an activated polymeric nanoparticle for targeted drug delivery that includes a biocompatible polymer and an amphiphilic stabilizing agent non-covalently associated with a spacer compound that includes at least one electrophile that selectively reacts with any nucleophilic on a targeting agent and places the targeting agent on the exterior surface of a biodegradable nanoshell, wherein an active agent is loaded with the nanoshell. |
申请公布号 |
AU2008240155(A1) |
申请公布日期 |
2008.10.23 |
申请号 |
AU20080240155 |
申请日期 |
2008.04.11 |
申请人 |
UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FORT WORTH |
发明人 |
JAMBOOR K. VISHWANATHA;ERICA KAFKA;ARTHUR R.C. BRADEN |
分类号 |
A61K9/14;B82B1/00 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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