发明名称 |
BIOMARKERS AND METHODS FOR DETERMINING SENSITIVITY TO VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 MODULATORS |
摘要 |
A method for predicting the likelihood a mammal will respond therapeutically to a method of treating cancer comprising administering a VEGFR-2 modulator or a dual VEGFR-2 / FGFR-1 modulator wherein the method comprises: (a) measuring in the mammal the level of FGF2; (b) either comparing the level of FGF2 in the sample relative to a standard to permit assignment of the sample to either being a member of an FGF2 positive class or an FGF2 negative class, or comparing the level of FGF2 in the sample relative to a standard, wherein assignment of the mammal to the FGF2 positive sample class or a determination that the mammal has an elevated level of FGF2, indicates an increased likelihood the patient will respond therapeutically to the cancer treatment. Methods of predicting whether a mammal has received an efficacious dose of a VEGFR-2 modulator or a dual VEGFR-2 / FGFR-1 modulator is also disclosed, in addition to kits comprising these methods. |
申请公布号 |
WO2008128008(A2) |
申请公布日期 |
2008.10.23 |
申请号 |
WO2008US59974 |
申请日期 |
2008.04.11 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;PARADA, JESUS PLATERO;GALBRAITH, SUSAN MARY |
发明人 |
PARADA, JESUS PLATERO;GALBRAITH, SUSAN MARY |
分类号 |
G01N33/50;C12Q1/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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