USE OF OLIGOTIDE FOR THE TREATMENT OF RENAL DISEASES

摘要

The present study has demonstrated that heparanase expression and activity was increased in human microvascular endothelial cells and rat kidney epithelial cells growing under hyperglycemia condition, as found in diabetic nephropathy disease. Oligotide was able to: -downregulate the heparanase gene expression; -downregulate the cell surface protein expression; -decrease the heparanase enzymatic activity. Since heparanase is a critical factor in maintaining glomerular basement membrane integrity and is elevated in renal diseases, as for instance diabetic nephropathies, Oligotide should be considered for the management of these diseases.