摘要 |
Provided herein are compounds that modulate the activity of a bacterial peptidyl tRNA hydrolase, including compositions and dosage forms comprising the compounds. Further provided herein are methods for screening and identifying compounds that modulate the activity of a bacterial peptidyl tRNA hydrolase. In particular, provided herein are assays for the identification of compounds that inhibit or reduce the activity of a bacterial peptidyl tRNA hydrolase. The methods provided herein provide a simple, sensitive assay for high- throughput screening of libraries of compounds to identify pharmaceutical leads useful for preventing, treating, and managing a bacterial infection or one or more symptoms thereof. Further provided herein are methods for preventing or inhibiting bacterial proliferation as well as methods for preventing, treating, and/or managing a bacterial infection using such compounds and compositions. |
申请人 |
PTC THERAPEUTICS, INC.;CHOI, SOONGYU;BRANSTROM, ARTHUR;GOTHE, SCOTT, A.;LIPMAN, RICHARD;TAMILARASU, NADARAJAN;WILDE, RICHARD, G. |
发明人 |
CHOI, SOONGYU;BRANSTROM, ARTHUR;GOTHE, SCOTT, A.;LIPMAN, RICHARD;TAMILARASU, NADARAJAN;WILDE, RICHARD, G. |