发明名称 |
DNA-PK INHIBITORS |
摘要 |
<p>The invention relates to the use of compounds of formula (I) and isomers, salts, solvates, chemically protected forms, and prodrugs thereof, in the preparation of a medicament for inhibiting the activity of DNA-PK, wherein R<SUP>1 </SUP>and R<SUP>2 </SUP>are independently hydrogen, an optionally substituted C<SUB>1-7 </SUB>alkyl group, C<SUB>3-20 </SUB>heterocyclyl group, or C<SUB>5-20 </SUB>aryl group, or may together form, along with the nitrogen atom to which they are attached, an optionally substituted heterocyclic ring having from 4 to 8 ring atoms; X and Y are selected from CR<SUP>4 </SUP>and O, O and CR'<SUP>4 </SUP>and NR''<SUP>4 </SUP>and N, where the unsaturation is in the appropriate place in the ring, and where one of R<SUP>3 </SUP>and R<SUP>4 </SUP>or R'<SUP>4 </SUP>is an optionally substituted C<SUB>3-20 </SUB>heteroaryl or C<SUB>5-20 </SUB>aryl group, and the other of R<SUP>3 </SUP>and R<SUP>4 </SUP>or R'<SUP>4 </SUP>is H, or R<SUP>3 </SUP>and R<SUP>4 </SUP>or R''<SUP>4 </SUP>together are -A-B-, which collectively represent a fused optionally substituted aromatic ring. The compounds also selectively inhibit the activity of DNA-PK compared to PI 3-kinase and/or ATM.</p> |
申请公布号 |
EP1417196(B1) |
申请公布日期 |
2008.10.22 |
申请号 |
EP20020751439 |
申请日期 |
2002.08.14 |
申请人 |
CANCER RESEARCH TECHNOLOGY LIMITED |
发明人 |
GRIFFIN, ROGER JOHN;GOLDING, BERNARD THOMAS;NEWELL, DAVID RICHARD;CALVERT, HILARY ALAN;CURTIN, NICOLA JANE;HARDCASTLE, IAN ROBERT;MARTIN, NIALL MORRISON BARR;SMITH, GRAEME CAMERON MURRAY;RIGOREAU, LAURENT JEAN MARTIN;COCKCROFT, XIAO-LING FAN;LOH, VINCENT JUNIOR MING-LAI;WORKMAN, PAUL;RAYNAUD, FLORENCE IRENE;NUTLEY, BERNARD PAUL |
分类号 |
C07D265/30;C07D309/38;A61K31/35;A61K31/352;A61K31/4025;A61K31/427;A61K31/453;A61K31/496;A61K31/519;A61K31/5375;A61K31/5377;A61K31/538;A61K31/541;A61K31/55;A61P9/00;A61P31/14;A61P35/00;A61P43/00;C07D311/22;C07D311/92;C07D405/04;C07D405/10;C07D405/12;C07D407/04;C07D407/12;C07D409/04;C07D409/12;C07D411/04;C07D413/04;C07D417/04;C07D453/02;C07D471/04 |
主分类号 |
C07D265/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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