Peptides binding to the Lck-SH3 and Hck-SH3 domains

摘要

The peptide His-Phe-Lys-Arg-Pro-Leu-Pro-Pro-Leu-Pro-Ser-Leu (I) is new. An independent claim is also included for complexes of (I) with the SH3 domains of human T-cell tyrosine kinase (Lck) and hematopoietic cell kinase (Hck). ACTIVITY : Anti-HIV; Virucide; Hepatotropic; Neuroprotective; Dermatological; Immunosuppressive; Antidiabetic; Antirheumatic; Antiarthritic; Antithyroid; Antiinflammatory; Ophthalmological; Nephrotropic; Cytostatic. MECHANISM OF ACTION : Human T-cell tyrosine kinase (Lck) inhibitor; Hematopoietic cell kinase (Hck) inhibitor.