Pharmaceutical compositions comprising atorvastatin manufactured without granulation

摘要

The present invention relates to a unit dosage form comprising atorvastatin or a pharmaceutically acceptable salt thereof, prepared without a granulation step, wherein the measured atorvastatin potency of said dosage form shows a relative standard deviation (RSD) for atorvastatin potency per unit dosage form of not more than about 7.8%, when said unit dosage form is prepared at a rate of greater than 10,000 unit dosage forms per hour per single unit dosage form per machine.