发明名称 |
DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE |
摘要 |
This invention is directed to compounds of formula (I): where r, q, R, R2, R3, R4, R5a, R5b, R5c, R6a, R6b, R6c, R7, R8, and R9 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions comprising the compounds of the invention and methods of preparing the compounds of the invention are also disclosed. |
申请公布号 |
EP1976828(A1) |
申请公布日期 |
2008.10.08 |
申请号 |
EP20060848156 |
申请日期 |
2006.12.22 |
申请人 |
SCHERING AKTIENGESELLSCHAFT |
发明人 |
ARNAIZ, DAMIAN;DAVEY, DAVID;GUILFORD, WILLIAM;CLEVE, ARWED;KIRKLAND, THOMAS;CLARET, EMMANUEL;KHIM, SEOCK-KYU;BROWN, GREG;YE, BIN;LIGHT, DAVID;LIANG, AMY;KOCHANNY, MONICA;WEI, GUO, PING;PARKINSON, JOHN |
分类号 |
C07D207/04;A61K31/13;A61K31/33;A61P29/00;C07C211/01;C07C211/43;C07D211/58;C07D243/08;C07D295/04;C07D295/16;C07D451/04;C07D487/08 |
主分类号 |
C07D207/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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