发明名称 |
UNAGGLOMERATED CORE/SHELL NANOCOMPOSITE PARTICLES |
摘要 |
The present invention provides a method for the synthesis of unagglomerated, highly dispersed, stable core/shell nanocomposite particles comprised of preparing a reverse micelle microemulsion that contains nanocomposite particles, treating the microemulsion with a silane coupling agent, breaking the microemulsion to form a suspension of the nanocomposite particles by adding an acid/alcohol solution to the microemulsion that maintains the suspension of nanocomposite particles at a pH of between about 6 and 7, and simultaneously washing and dispersing the suspension of nanocomposite particles, preferably with a size exclusion HPLC system modified to ensure unagglomeration of the nanocomposite particles. The primary particle size of the nanocomposite particles can range in diameter from between about 1 to 100 nm, preferably from between about 10 to 50 nm, more preferably about 10 to 20 nm, and most preferably about 20 nm. |
申请公布号 |
EP1773936(A4) |
申请公布日期 |
2008.10.08 |
申请号 |
EP20050804865 |
申请日期 |
2005.06.01 |
申请人 |
THE PENN STATE RESEARCH FOUNDATION |
发明人 |
ADAIR, JAMES H.;ROUSE, SARAH M.;WANG, JUN;KESTER, MARK;SIEDLECKI, CHRISTOPHER;WHITE, WILLIAM B.;VOGLER, ERWIN;SNYDER, ALAN;PANTANO, CARLO, G.;SINOWAY, LAWRENCE;RUIZ-VELASCO, VICTOR |
分类号 |
A61K9/16;A61K9/14;A61K47/48;B01J13/02;C08K9/02 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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