4,6-diamino-[1,7]naphthyridine-3-carbonitrile inhibitors of Tpl2 kinase and methods of making and using the same

摘要

The present invention provides compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R¹, R², R³, R⁴, R⁵r⁶, m and n are defined as described herein. The invention also provides methods of making the compounds of formula (I), and methods of treating inflammatory diseases, such as rheumatoid arthritis, in a mammal comprising administering a therapeutically effective amount of a compound of formula (I) to the mammal.