发明名称 |
Transgenic mouse having an amyloid precursor protein with a modified beta secretase cleavage site |
摘要 |
The present invention provides transgenic animals having an amyloid precursor protein wherein the amino acids flanking the beta secretase cleavage site are NF and EV. The invention also provides tissues and cell lines derived from such animals. The invention further provides methods of screening candidate compounds to determine whether the compounds can alter the rate of cleavage of amyloid precursor protein by beta secretase.
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申请公布号 |
US7432414(B2) |
申请公布日期 |
2008.10.07 |
申请号 |
US20040558656 |
申请日期 |
2004.05.28 |
申请人 |
MERCK & CO., INC. |
发明人 |
CHEN RICHARD Z.;SIMON ADAM J.;VOGT THOMAS F. |
分类号 |
A01K67/027;C07K14/47;C12N15/85;G01N33/00 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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