| 发明名称 |
THIOAMIDE DERIVATIVES |
| 摘要 |
Compounds of formula (1): and the pharmaceutically acceptable salts and esters thereof wherein X and Y are as defined in the specification, inhibit the binding of VCAM-1 to VLA-4 and are useful in treating inflammation associated with chronic inflammatory diseases such as rheumatoid arthritis (RA), multiple sclerosis (MS), asthma, and inflammatory bowel disease (I/BD).
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| 申请公布号 |
CA2362831(C) |
申请公布日期 |
2008.10.07 |
| 申请号 |
CA20002362831 |
申请日期 |
2000.02.10 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
SIDDURI, ACHYTHARAO;TILLEY, JEFFERSON WRIGHT;HULL, KENNETH GREGORY |
| 分类号 |
C07C327/46;A61K31/145;A61K31/165;A61K31/167;A61K31/198;A61K31/223;A61K31/4164;A61K31/4166;A61K31/44;A61K31/4406;A61K31/4409;A61K31/505;A61P1/00;A61P11/06;A61P29/00;A61P43/00;C07C327/48;C07D213/56;C07D213/82;C07D233/38;C07D233/84;C07D239/26;C07D239/28;C07D401/06 |
主分类号 |
C07C327/46 |
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