发明名称 |
High-affinity choline transporter |
摘要 |
The present invention provides a protein having high-affinity choline transporter activity which is important physiologically, a gene encoding the protein, and a method of screening a material promoting the high-affinity choline transporter activity with the use of the same, and the like. By examining high-affinity choline uptake activity of Na<SUP>+</SUP>-dependent transporter cDNA deduced from the genomic sequence of a nematode (C. elegans) in a Xenopus oocyte expression system, the cDNA (cho-1) of nematode high-affinity choline transporter is identified. Then the cDNA (CHT1) of rat high-affinity choline transporter is cloned from rat spinal cord by using the homology of a base sequence to this cDNA as an index. Similarly, the cDNA of human high-affinity choline transporter is cloned from human genome.
|
申请公布号 |
US7432077(B1) |
申请公布日期 |
2008.10.07 |
申请号 |
US20000069541 |
申请日期 |
2000.08.18 |
申请人 |
JAPAN SCIENCE AND TECHNOLOGY AGENCY |
发明人 |
HAGA TATSUYA;OKUDA TAKASHI |
分类号 |
C12N15/09;C12P21/06;A01K67/027;A61K38/00;A61K39/00;A61K48/00;A61P25/28;C07H21/02;C07H21/04;C07K1/00;C07K14/435;C07K14/47;C07K14/705;C07K16/18;C07K19/00;C12N1/20;C12N5/10;C12N15/12;C12P21/02;C12P21/04;C12P21/08;C12Q1/00;G01N33/50;G01N33/68 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|