发明名称 |
Gossypol co-crystals and the use thereof |
摘要 |
This invention relates to compositions comprising co-crystals of (-)-gossypol with a C<SUB>1-8 </SUB>carboxylic acid or C<SUB>1-8 </SUB>sulfonic acid which are useful as inhibitors of Bcl-2 family proteins. The invention also relates to the use of co-crystals of (-)-gossypol with a C<SUB>1-8 </SUB>carboxylic acid or C<SUB>1-8 </SUB>sulfonic acid for inducing apoptosis in cells and for sensitizing cells to the induction of apoptotic cell death.
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申请公布号 |
US7432300(B2) |
申请公布日期 |
2008.10.07 |
申请号 |
US20070818766 |
申请日期 |
2007.06.15 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
WANG SHAOMENG;CHEN JIANGYONG |
分类号 |
A61K31/225;A61K31/11;A61K31/70 |
主分类号 |
A61K31/225 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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