1-Amino Linked Compounds

摘要

The present invention is directed to compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein A is (II); X is selected from CH, CF and N, R8 is selected from H, C₁-C₆ alkyl, aryl, heteroaryl, C₁-C₆ alkylaryl, C₁-C₆ alkylheteroaryl, C₂-C₆ alkyl-O-C₁-C₆ alkyl, C₁-C₆ haloalkyl, hydroxy C₂-C₆ alkyl, -C(O)R9 and -SO₂R9, or R7 and R8 combine to form (III), (IV); W is selected from CR1O and CR15, R1O is selected from H, halo, -C(O)NR13R14, C₁-C₆ alkyl, aryl, heteroaryl, C₁-C₆ alkylaryl, C₁-C₆ alkylheteroaryl, C₁-C₆ alkyl-O-C₁-C₆ alkyl and hydroxy C₁-C₆ alkyl; Het is a N-linked 5-membered heteroaryl ring optionally substituted with 1-3 substituents selected from methoxy, Cl, F, CH₃, CF₃, aryl, heteroaryl, C₁-C₄ alkylaryl or C₁-C₄ alkylheteroaryl, for use as inhibitors of the DPP-IV enzyme in the treatment or prevention of conditions including Type II diabetes.