MONO- AND DI-ORGANIC AMINE SALT, MONO- AND DI-AMINO ACID SALT, AND MONO- AND DI-AMINO ACID ESTER SALT OF COMBRETASTATIN A-4 PHOSPHATE PRODRUG

摘要

PROBLEM TO BE SOLVED: To provide a new and useful combretastatin A-4 prodrug salt having preferable physico-chemical characteristics. SOLUTION: The invention provides the new and useful mono- and di-organic amine salt, mono- and di-amino acid salt, and mono- and di-amino acid ester salt of the combretastatin A-4 prodrug, and the prodrugs increase the solubility of combretastatin A-4, readily regenerate combretastatin A-4 in vivo under normal physiological condition, and which produce physiologically tolerable products as a result of the regeneration of combretastatin A-4. COPYRIGHT: (C)2008,JPO&INPIT