Compositions and Method for Increasing the Efficacy of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors

摘要

Compositions and methods for increasing the efficacy of an epidermal growth factor receptor-tyrosine kinase inhibitor are provided. The drugs are modified stereospecific epidermal growth factor receptor-tyrosine kinase inhibitors that upon modification are able to accumulate at higher levels in tumor cells thereby increasing the efficacy of the inhibitor.